Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Type I Diabetes III: Clinical Manifestations

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medication Adherence in Pediatric Sickle Cell Disease and Hematopoietic Stem Cell Transplantation: An Integrative Review of Literature.

Journal of pediatric hematology/oncology nursing·2026

Same author

Normalization of Deviance: A Nursing Concept Analysis.

Journal of nursing care quality·2026

Same author

The Silent Struggle: Understanding Factors Influencing Veterans' Mental Healthcare-Seeking Behaviour Through an Integrative Review.

Issues in mental health nursing·2026

Same author

The impact of digital storytelling on psychosocial well-being in individuals with type 1 diabetes: a randomized clinical trial study in Iran.

BMC psychology·2025

Same author

The Impact of Home Care on Glycosylated Hemoglobin and Quality of Life in Type 2 Diabetes Patients Discharged After Surgery.

SAGE open nursing·2025

Same author

Two distinct psychological concepts: Diabetes depression and diabetes burnout profiles.

Journal of education and health promotion·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

Exploring diabetes type 1-related stigma.

Samereh Abdoli¹, Parvaneh Abazari, Leila Mardanian

¹Nursing and Midwifery Care Research Centre, Department of Adult Nursing, Isfahan University of Medical Sciences, Isfahan, Iran.

Iranian Journal of Nursing and Midwifery Research

|August 29, 2013

Summary

This summary is machine-generated.

People with type 1 diabetes in Isfahan face significant stigma, being viewed as burdens and rejected for marriage. This social stigma hinders their empowerment and integration of diabetes with identity.

Keywords:

Diabetes Iran disease-related stigma people with diabetes qualitative research social stigma

More Related Videos

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Area of Science:

Medical Sociology
Endocrinology
Public Health

Background:

Diabetes empowerment involves integrating the condition with personal identity.
Social stigma significantly impacts diabetes empowerment.
Limited research exists on diabetes-related stigma in Iran, despite high prevalence.

Purpose of the Study:

To explore diabetes-related stigma experienced by individuals with type 1 diabetes in Isfahan, Iran.

Main Methods:

Conventional content analysis of in-depth interviews.
Involved 26 participants with and without diabetes.
Data collected between November 2011 and July 2012.

Main Results:

Individuals with type 1 diabetes were stigmatized as "miserable humans" (sickly, burdensome, death reminders).
They faced rejection as marriage candidates due to perceived risks (pregnancy, spousal burden).
Participants felt deprived of a normal life, viewing themselves as "prisoners of musts" and pleasure.

Conclusions:

Diabetes-related stigma is a significant issue in Isfahan.
Interventions are crucial to improve empowerment for people with type 1 diabetes.
Reducing social stigma is necessary to enhance the empowerment process.