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Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
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Should Finasteride Be Routinely Given Preoperatively for TURP?

O M Aboumarzouk1, M Z Aslam, A Wedderburn

  • 1Department of Urology, University Hospital of Wales, Cardiff CF14 4XW, UK.

ISRN Urology
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Finasteride use before transurethral resection of the prostate (TURP) surgery may reduce bleeding. This review found finasteride potentially lowers intraoperative and postoperative bleeding in TURP patients.

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Area of Science:

  • Urology
  • Pharmacology

Background:

  • Transurethral resection of the prostate (TURP) is a common procedure for benign prostatic hyperplasia.
  • Bleeding is a known complication associated with TURP.
  • Finasteride is a medication used to treat prostate conditions.

Purpose of the Study:

  • To evaluate the efficacy of finasteride in reducing bleeding during and after TURP procedures.
  • To compare finasteride's effects against a placebo in patients undergoing TURP.

Main Methods:

  • A systematic review of randomized controlled trials was conducted.
  • Searches included major databases like CENTRAL, MEDLINE, EMBASE, CINAHL, Clinicaltrials.gov, and Google Scholar.
  • Studies comparing finasteride to placebo in TURP patients were included without language restriction.

Main Results:

  • Four randomized controlled trials were identified.
  • Three studies indicated that finasteride reduced intraoperative or postoperative bleeding.
  • One study demonstrated finasteride's ability to decrease microvessel density (MVD) and vascular endothelial growth factor (VEGF).
  • No long-term complications were reported for either finasteride or the TURP procedure.

Conclusions:

  • Finasteride appears to reduce bleeding associated with TURP.
  • Further research may be warranted to confirm these findings and explore mechanisms.