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Updated: May 8, 2026
02:28
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Multiple keratoacanthomas developing in healing plaques of Psoriasis
Vineet Relhan1, Surabhi Sinha, Nita Khurana
1Department of Dermatology and STD, Maulana Azad Medical College and Lok Nayak Hospital, Delhi, India.
Indian Dermatology Online Journal
|August 29, 2013
Summary
Psoriatic patients on methotrexate may develop keratoacanthomas. This case highlights potential links between immunosuppression, genetic factors, and keratoacanthoma development in psoriasis patients.
Area of Science:
- Dermatology
- Oncology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Methotrexate is a common systemic treatment for moderate to severe psoriasis.
- Keratoacanthomas are rapidly growing skin tumors.
Observation:
- A 22-year-old male psoriatic patient on methotrexate developed multiple keratoacanthomas.
- Lesions appeared as nodules with central craters on healing psoriatic plaques.
- Some lesions demonstrated spontaneous resolution within 6-12 weeks.
Findings:
- Histopathology confirmed the lesions as keratoacanthomas.
- The patient's Psoriasis Area and Severity Index (PASI) score improved significantly with methotrexate treatment.
- The development of multiple keratoacanthomas occurred during methotrexate therapy.
Implications:
- This case suggests a potential association between methotrexate therapy for psoriasis and keratoacanthoma development.
- Genetic susceptibility may play a role in the development of multiple keratoacanthomas in psoriatic patients.
- Further research is needed to elucidate the exact relationship between psoriasis, methotrexate, and keratoacanthoma.
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