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Related Experiment Video

Updated: May 8, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Hierarchically engineered fibrous scaffolds for bone regeneration.

Nadège Sachot1, Oscar Castaño, Miguel A Mateos-Timoneda

  • 1Biomaterials for Regenerative Therapies, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15-21, 08028 Barcelona, Spain.

Journal of the Royal Society, Interface
|August 30, 2013
PubMed
Summary

This study developed a new coating for fibrous scaffolds, mimicking bone extracellular matrix. The enhanced biomaterial surface properties improved stem cell interactions and directed cell fate.

Keywords:
fibresfunctional coatinghybrid materialsnanostructurestissue engineering

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Last Updated: May 8, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

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Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Stem Cell Biology

Background:

  • Surface properties of biomaterials critically influence cell functions like proliferation and differentiation.
  • Mechanical, chemical, and nanotopographic cues are key factors in cell behavior.
  • Mimicking the natural bone extracellular matrix is crucial for effective bone tissue regeneration.

Purpose of the Study:

  • To develop a novel coating protocol for creating hierarchically engineered fibrous scaffolds.
  • To engineer tailorable surface characteristics that mimic the bone extracellular matrix.
  • To investigate the impact of these engineered surfaces on stem cell behavior.

Main Methods:

  • Utilized the sol-gel method combined with surface treatments to coat hollow electrospun polylactic acid fibers.
  • Coated fibers with a silicon-calcium-phosphate bioactive organic-inorganic glass.
  • Characterized surface topography, roughness, hydrophilicity, and mechanical properties (Young's modulus).

Main Results:

  • Coated fibers exhibited nanostructured topography and increased roughness compared to smooth, uncoated fibers.
  • Enhanced hydrophilic properties and a sixfold higher Young's modulus were observed in coated fibers.
  • Rat mesenchymal stem cells demonstrated significant cellular spreading and interaction on the coated scaffolds.

Conclusions:

  • The novel coating protocol successfully produced biomimetic fibrous scaffolds with tunable surface properties.
  • The engineered surface characteristics effectively promoted stem cell adhesion and spreading.
  • This approach offers a valuable method for fabricating artificial matrices that direct stem cell fate via physical and chemical cues.