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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Updated: May 8, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Breast cancer stem cells.

Thomas W Owens¹, Matthew J Naylor

¹Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney Sydney, NSW, Australia.

Frontiers in Physiology

|August 30, 2013

Summary

This summary is machine-generated.

Breast cancer recurrence and treatment resistance are linked to cancer stem cells (CSCs). Understanding CSC origins and roles is key to developing new therapies targeting these cells for improved patient survival.

Keywords:

breast cancer cancer stems cells cell fate mammary gland transcription factors

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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

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Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines

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Published on: March 22, 2015

Area of Science:

Oncology
Cancer Biology
Stem Cell Research

Background:

Breast cancer metastasis, therapeutic resistance, and recurrence pose significant challenges to patient survival.
Cancer stem cells (CSCs) are increasingly implicated in driving breast cancer progression and recurrence.
Elucidating the mechanisms of CSC formation and function is crucial for advancing treatment strategies.

Purpose of the Study:

To review the current understanding of the origins of breast cancer stem cells (CSCs).
To summarize the role of CSCs in breast cancer progression and recurrence.
To explore potential therapeutic strategies targeting CSCs.

Main Methods:

Literature review of recent research on breast cancer stem cells.
Synthesis of evidence regarding CSC origins and their contribution to tumor pathology.
Analysis of therapeutic approaches targeting CSCs.

Main Results:

Evidence suggests CSCs play a critical role in breast cancer metastasis, treatment resistance, and recurrence.
Understanding CSC origins provides insights into their function in disease progression.
Various therapeutic strategies are being developed to target CSCs.

Conclusions:

Cancer stem cells are pivotal in the progression and recurrence of breast cancer.
Targeting CSCs holds promise for overcoming therapeutic resistance and improving patient outcomes.
Further research into CSC biology is essential for developing effective, targeted breast cancer therapies.