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Related Experiment Video

Updated: May 8, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

The dose-response relationship between pseudoephedrine ingestion and exercise performance.

Kellie R Pritchard-Peschek1, David G Jenkins1, Mark A Osborne2

  • 1School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia.

Journal of Science and Medicine in Sport
|August 31, 2013
PubMed
Summary

This study found that pseudoephedrine did not improve cycling performance in trained cyclists. Individual differences in how the body processes pseudoephedrine may explain varied performance outcomes.

Keywords:
Cycling time-trialErgogenic aidPlasma concentrationPseudoephedrine

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Last Updated: May 8, 2026

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Published on: December 19, 2024

Area of Science:

  • Exercise Physiology
  • Sports Science
  • Pharmacology

Background:

  • Pseudoephedrine is a stimulant sometimes used to enhance athletic performance.
  • Its effects on endurance exercise, particularly cycling time trial performance, require further investigation.

Purpose of the Study:

  • To investigate the dose-response relationship between pre-exercise pseudoephedrine intake and cycling time trial performance.
  • To assess the impact of different pseudoephedrine dosages on physiological markers.

Main Methods:

  • A randomized, double-blind, crossover trial involving ten trained male cyclists.
  • Participants completed three cycling time trials after ingesting placebo, 2.3 mg/kg, or 2.8 mg/kg pseudoephedrine.
  • Blood samples were analyzed for pH, lactate, glucose, and catecholamine concentrations.

Main Results:

  • Pseudoephedrine ingestion did not enhance cycling time trial performance.
  • Plasma pseudoephedrine concentrations were dose-dependent (2.8 mg/kg > 2.3 mg/kg > placebo).
  • Significant individual variability in plasma pseudoephedrine concentrations was observed.

Conclusions:

  • Pseudoephedrine does not appear to improve cycling time trial performance in trained athletes.
  • Individual variability in pseudoephedrine pharmacokinetics may contribute to inconsistent performance effects.
  • Further research is needed to understand factors influencing pseudoephedrine absorption and efficacy.