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The stability of lisinopril as an extemporaneous syrup
A A Webster1, B A English, D J Rose
1Pharmacokinetics Center, McWhorter School of Pharmacy, Samford University, Birmingham, AL.
Abstract:
The stability of lisinopril as an extemporaneous syrup compounded from powder was studied. The lisinopril syrup (2mg/mL) was prepared by incorporating lisinopril powder dissolved in water into simple syrup. Samples of the syrup were stored in amber-colored plastic bottles at 5 and 23 deg C. At various times during the 30-day study period, the concentration of lisinopril waas determined by a stability-indicating high performance liquid chromatography assay procedure. Samples were also visually inspeceted for color and clarity. Over the 30-day study period, the percentage of the initial concentration remained between 97.46% and 100.54% for the 23 deg C samples and 98.15% and 100.74% for the 5 deg C samples.
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