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Stability of indomethacin in 0.9% sodium chloride injection
1Pharmaceutics Division, University of Houston, Houston, TX.
Abstract:
The stability of indomethacin (from indomethacin sodium trihydrate powder for injection) in preservative-free 0.9% sodium chloride injection has been studied using a stability-indicating high-performance liquid chromatography assay method. The method described is precise and accurate, with a percent relative standard deviation of 0.7% based on five readings. The 0.1-mg/mL solutions were stable for at least ten days when stored at roomtemperature in 10-mL plastic vials in which the sodium chloride injections are marketed. The solutions remained clear throughout the study;and pH values did increase by about 0.5 units, since the admixtures were not buffered.
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