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Updated: May 8, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
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Paclitaxel Compatibility with the IV Express Filter Unit.

Q A Xu1, L A Trissel, Y Zhang

  • 1MD Anderson Hospital, Houston, TX.

International Journal of Pharmaceutical Compounding
|August 31, 2013
PubMed
Summary
This summary is machine-generated.

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The IV Expres filter unit is compatible with paclitaxel infusions. This study found no detectable plasticizer leaching or paclitaxel loss during three-hour infusions, ensuring safe drug delivery.

Area of Science:

  • Oncology
  • Pharmaceutical Sciences
  • Medical Device Engineering

Background:

  • Paclitaxel is a crucial chemotherapy agent.
  • Intravenous filters are used to ensure drug purity.
  • Concerns exist regarding potential leaching and sorption with certain drug-filter combinations.

Purpose of the Study:

  • To assess the compatibility of paclitaxel infusions with the IV Expres filter unit.
  • To evaluate the potential for diethylhexyl phthalate plasticizer extraction by Cremaophor EL.
  • To determine paclitaxel loss due to sorption with filter components.

Main Methods:

  • Simulated three-hour infusions of paclitaxel using the IV Expres filter unit.
  • Analysis of plasticizer extraction using paclitaxel diluent (1.2 mg/mL).

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Last Updated: May 8, 2026

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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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  • Evaluation of paclitaxel delivery (0.3 mg/mL) via high-performance liquid chromatography.

    • Main Results:

    • No detectable diethylhexyl phthalate plasticizer was found in any samples.
    • No paclitaxel loss due to sorption to filter components was observed.
    • Full paclitaxel delivery was confirmed in all simulated infusions.

    Conclusions:

    • The IV Expres filter unit is suitable for administering paclitaxel infusions.
    • The filter unit does not leach plasticizers or cause drug loss during infusion.
    • This confirms the safety and efficacy of using the IV Expres filter with paclitaxel.