Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 8, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Paclitaxel Compatibility with the IV Express Filter Unit.

Q A Xu1, L A Trissel, Y Zhang

  • 1MD Anderson Hospital, Houston, TX.

International Journal of Pharmaceutical Compounding
|August 31, 2013
PubMed
Summary

The IV Expres filter unit is compatible with paclitaxel infusions. This study found no detectable plasticizer leaching or paclitaxel loss during three-hour infusions, ensuring safe drug delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Research progress in ecological prevention of dental caries].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2022
Same author

[The imaging characteristics and prognosis of patients with cochlear implants whose cochlear nerves are not shown on MRI].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2021
Same author

[3D-FLAIR MRI findings in idiopathic sudden sensorineural hearing loss and the correlations with clinical features and prognosis].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2021
Same author

Physician deaths from corona virus (COVID-19) disease.

Occupational medicine (Oxford, England)·2020
Same author

Compounding an extended-stability admixture of Paclitaxel for long-term infusion.

International journal of pharmaceutical compounding·2013
Same author

Stability of aminocaproic Acid injection admixtures in 5% dextrose injection and 0.9% sodium chloride injection.

International journal of pharmaceutical compounding·2013

Area of Science:

  • Oncology
  • Pharmaceutical Sciences
  • Medical Device Engineering

Background:

  • Paclitaxel is a crucial chemotherapy agent.
  • Intravenous filters are used to ensure drug purity.
  • Concerns exist regarding potential leaching and sorption with certain drug-filter combinations.

Purpose of the Study:

  • To assess the compatibility of paclitaxel infusions with the IV Expres filter unit.
  • To evaluate the potential for diethylhexyl phthalate plasticizer extraction by Cremaophor EL.
  • To determine paclitaxel loss due to sorption with filter components.

Main Methods:

  • Simulated three-hour infusions of paclitaxel using the IV Expres filter unit.
  • Analysis of plasticizer extraction using paclitaxel diluent (1.2 mg/mL).
  • Evaluation of paclitaxel delivery (0.3 mg/mL) via high-performance liquid chromatography.

Main Results:

  • No detectable diethylhexyl phthalate plasticizer was found in any samples.
  • No paclitaxel loss due to sorption to filter components was observed.
  • Full paclitaxel delivery was confirmed in all simulated infusions.

Conclusions:

  • The IV Expres filter unit is suitable for administering paclitaxel infusions.
  • The filter unit does not leach plasticizers or cause drug loss during infusion.
  • This confirms the safety and efficacy of using the IV Expres filter with paclitaxel.

More Related Videos

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Related Experiment Videos

Last Updated: May 8, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016