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[Molecular surveillance shows progress in measles elimination process]

S Santibanez1, A Mankertz

  • 1Fachgebiet Masern, Mumps, Röteln und Viren bei Abwehrschwäche, Nationales Referenzzentrum Masern, Mumps, Röteln, Robert Koch-Institut, Nordufer 20, 13353, Berlin, Deutschland. santibanezs@rki.de

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|August 31, 2013
PubMed

Insights

Global measles elimination is achievable with high vaccination rates. Genotyping measles virus strains is crucial for tracking transmission chains and supporting elimination efforts in Germany.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Measles is a severe viral illness with a significant fatality rate in industrialized nations.
  • Global measles elimination is feasible through widespread vaccination with the measles, mumps, and rubella (MMR) vaccine, targeting over 95% coverage.
  • The WHO Europe region aimed for measles and rubella elimination by 2015.

Purpose of the Study:

  • To analyze the duration of measles virus transmission chains initiated by imported cases.
  • To assess the effectiveness of measles virus genotyping in assigning viruses to specific outbreaks and chains.
  • To summarize experiences and new developments in measles virus genotyping for measles elimination in Germany.

Main Methods:

  • Continuous genetic characterization (genotyping) of measles viruses since 1999.
  • Analysis of transmission chains initiated by imported measles virus.
  • Utilizing data from the German Intervention Program and the National Reference Center for Measles, Mumps, Rubella.

Main Results:

  • Genotyping is essential for assigning measles viruses to outbreaks and transmission chains.
  • Long-term surveillance and genotyping have provided valuable data for measles elimination strategies.
  • The article details experiences and advancements in measles virus genotyping within the German context.

Conclusions:

  • Effective measles elimination requires robust surveillance and genetic characterization of the virus.
  • Understanding transmission dynamics through genotyping is key to interrupting measles spread.
  • Continued genotyping efforts support national and regional measles elimination goals.

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