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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Estrogen receptor α roles in breast cancer chemoresistance

Chao-Yang Xu1, Zhi-Nong Jiang, Ying Zhou

  • 1Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, China. shaoxinghlm@126.com

Asian Pacific Journal of Cancer Prevention : APJCP
|September 3, 2013
PubMed

Insights

Estrogen receptor alpha (ERα) expression in breast cancer cells is linked to reduced chemotherapy sensitivity. Understanding ERα

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Chemotherapy resistance limits systemic therapy efficacy in breast cancer.
  • Mechanisms of resistance include factors like estrogen receptor alpha (ERα), P-glycoprotein, and others.
  • ERα is a ligand-activated transcription factor crucial for endocrine signaling.

Purpose of the Study:

  • To review the predictive value of ERα expression in breast cancer response to chemotherapy.
  • To elucidate the role of ERα in chemotherapy resistance.

Main Methods:

  • Review of preclinical and clinical studies.
  • Analysis of existing knowledge on ERα expression and chemotherapy sensitivity.

Main Results:

  • Positive ERα expression in breast cancer cells has been correlated with decreased sensitivity to chemotherapy.
  • ERα plays a significant role in the mechanisms of chemotherapy resistance.

Conclusions:

  • Understanding the predictive value of ERα is crucial for chemotherapy response.
  • Targeting ERα or utilizing its predictive value may optimize patient selection for therapeutic regimens.
  • Improved understanding can lead to better clinical outcomes in breast cancer treatment.

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