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Published on: June 10, 2017
Gene expression profiling of non-hodgkin lymphomas
Abdel-Rahman Nabawy Zekri1, Zeinab Korany Hassan, Abeer Ahmed Bahnassy
1Virology and Immunology Unit, Cancer Biology Department, Faculty of Medicine National Cancer Institute, Cairo University, Cairo, Egypt.
Asian Pacific Journal of Cancer Prevention : APJCP
|September 3, 2013
Summary
This study identified novel gene expression changes in Egyptian non-Hodgkin lymphoma (NHL) cases. These differentially expressed genes could serve as potential biomarkers for NHL diagnosis and risk assessment.
Area of Science:
- Genomics
- Molecular Biology
- Oncology
Background:
- Chromosomal translocations are key genetic alterations in non-Hodgkin lymphoma (NHL) subtypes.
- Understanding gene expression profiles is crucial for NHL subtyping and diagnosis.
Purpose of the Study:
- To investigate the differential gene expression profile in Egyptian NHL cases.
- To identify novel gene expression markers associated with NHL.
Main Methods:
- Microarray analysis of tissue samples from 40 NHL patients and 20 controls.
- Quantitative real-time polymerase chain reaction (qRT-PCR) for validation of gene expression.
Main Results:
- Identified 8 significantly up-regulated and 4 down-regulated genes in NHL.
- Observed aberrant expression of previously unreported genes, including down-regulated NAG14 protein and up-regulated Rb binding protein 5.
Conclusions:
- New differentially expressed genes were identified in NHL.
- These genes may serve as potential biomarkers for NHL patients and cancer risk assessment.
