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Percutaneous coronary intervention vs. optimal medical therapy--the other side of the coin: medication adherence

C Kocas1, O Abaci, V Oktay

  • 1Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.

Journal of Clinical Pharmacy and Therapeutics
|September 3, 2013
PubMed

Insights

Patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) showed significantly higher medication adherence than those on optimal medical therapy (OMT) alone. Careful monitoring of adherence is crucial for OMT patients.

Area of Science:

  • Cardiology
  • Pharmacology
  • Health Services Research

Background:

  • Medication adherence is critical for managing coronary artery disease (CAD).
  • Previous studies on adherence in CAD patients are limited, with no prospective trials comparing percutaneous coronary intervention (PCI) and optimal medical therapy (OMT).

Purpose of the Study:

  • To compare medication adherence to secondary preventive medications in CAD patients treated with PCI plus OMT versus OMT alone in a real-world setting.

Main Methods:

  • A 6-month follow-up study of 232 patients with documented CAD.
  • Compared adherence to statins, beta-blockers, and ACE inhibitors between patients receiving PCI and those on OMT alone.
  • Medication adherence was assessed using national reimbursement database records.

Main Results:

  • Medication adherence was significantly higher in the PCI group (53.6%) compared to the OMT group (33.8%) (P=0.004).
  • Higher adherence rates were observed in the PCI group for beta-blockers (86.0% vs 72.5%, P=0.006) and statins (64.5% vs 44.0%, P=0.003).
  • PCI treatment was an independent predictor of medication adherence (B=2.20, P=0.03).

Conclusions:

  • Adherence to evidence-based secondary preventive medications is significantly higher in CAD patients treated with PCI compared to OMT alone.
  • Medication adherence requires careful monitoring, particularly in CAD patients managed with OMT.
Abstract

Keywords:
coronary artery diseasemedication adherenceoptimal medical therapypercutaneous coronary intervention

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