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Related Experiment Video

Updated: May 8, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Modelling propofol pharmacodynamics using BIS-guided anaesthesia.

I Martín-Mateos¹, J A Méndez Pérez, J A Reboso

¹Universidad de La Laguna, La Laguna, Tenerife, Spain.

|September 3, 2013

Summary

This study modeled propofol pharmacodynamics during anesthesia using Schnider

Area of Science:

Anesthesiology
Pharmacokinetics
Pharmacodynamics

Background:

Total intravenous anesthesia (TIVA) relies on precise drug administration.
Understanding propofol's concentration-effect relationship is crucial for safe TIVA.
Remifentanil co-administration can influence anesthetic depth.

Purpose of the Study:

To model propofol pharmacodynamics during TIVA using Schnider's pharmacokinetic model.
To estimate key pharmacodynamic parameters (Ce50 and γ) for induction and maintenance phases.
To investigate the influence of age and sex on propofol's effects.

Main Methods:

Utilized Schnider's pharmacokinetic model to analyze data from 42 surgical patients.
Adjusted the pharmacokinetic/pharmacodynamic model based on bispectral index (BIS) data.

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Estimated Ce50 (concentration for 50% effect) and γ (slope factor) for induction and maintenance.

Main Results:

Distinct pharmacodynamic models were identified for propofol induction and maintenance.
Higher propofol concentrations (Ce50) were required for induction (3.35 mg/L) compared to maintenance (2.23 mg/L).
The concentration-effect slope (γ) was steeper during maintenance (1.58) than induction (1.24), indicating greater patient response.

Conclusions:

Propofol's pharmacodynamic profile differs significantly between induction and maintenance phases.
Age demonstrated a linear relationship with propofol's effect concentration (Ce50).
Sex did not significantly impact the propofol pharmacokinetic/pharmacodynamic model.