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Lymphomas: MR imaging contrast characteristics with clinical-pathologic correlations.
W G Negendank1, A M al-Katib, C Karanes
1Vaitkevicius MR Center, Harper Hospital, Detroit, MI 48201.
Radiology
|October 1, 1990
Summary
Magnetic resonance imaging (MRI) reveals lymphomas are typically homogeneous. Dense fibrosis in lymphomas significantly increases their brightness on T2-weighted images, impacting Hodgkin disease and mediastinal lymphoma appearance.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Lymphomas, including Hodgkin disease and non-Hodgkin lymphomas, are significant hematologic malignancies.
- Accurate imaging characteristics are crucial for diagnosis and staging.
Purpose of the Study:
- To characterize the T1-weighted and T2-weighted magnetic resonance imaging (MRI) features of lymphomas.
- To investigate the relationship between lymphoma characteristics, such as fibrosis and grade, and their MRI signal intensities.
Main Methods:
- T1-weighted and T2-weighted MRI at 1.5 T were performed on 32 patients with non-Hodgkin lymphomas and 20 with Hodgkin disease.
- Mean pixel intensity ratios, contrast parameters, and T1-T2 cross products relative to fat and muscle were calculated.
Main Results:
- Lymphomas generally exhibited homogeneous pixel intensity distributions.
- On average, lymphomas were hypointense to fat and slightly hyperintense to muscle on T1-weighted images, and isointense to fat and hyperintense to muscle on T2-weighted images.
- Increased brightness on T2-weighted images was significantly associated with dense fibrosis within lymphomas, explaining higher signal in Hodgkin disease and mediastinal lymphomas.
Conclusions:
- Simple mean pixel intensity ratios on T1- and T2-weighted MRI effectively characterize lymphomas.
- Fibrosis is a key determinant of T2-weighted signal intensity in lymphomas, influencing the appearance of Hodgkin disease and mediastinal involvement.