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Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin

Jean Marie Ruddy1, Jeffery A Jones, John S Ikonomidis

  • 1Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charlston, SC, USA.

Progress in Cardiovascular Diseases
|September 3, 2013
PubMed

Keywords:
AAAAT1AngIIECMERKExtracellular matrix remodelingMMPMatrix metalloproteinasesTAATGF-βTGF-βR1 & 2Thoracic Aortic AneurysmTransforming growth factor-betaVSMCabdominal aortic aneurysmangiotensin IIangiotensin receptor 1extracellular matrixextracellular signal-regulated kinasematrix metalloproteinaset-PAthoracic aortic aneurysmtissue plasminogen activatortransforming growth factor betatransforming growth factor beta receptor 1 & 2vascular smooth muscle cell

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