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Chronobiology in aortic diseases - "is this really a random phenomenon?"
Roberto Manfredini1, Fabio Fabbian, Fabio Manfredini
1Clinica Medica, Department of Medical Sciences, University of Ferrara, Italy. roberto.manfredini@unife.it
Progress in Cardiovascular Diseases
|September 3, 2013
Summary
Acute aortic dissection, a rare cause of sudden death, shows temporal patterns similar to other cardiovascular events. These variations may stem from shared pathophysiological mechanisms or disruptions in biological clock molecular processes.
Area of Science:
- Cardiovascular Medicine
- Chronobiology
- Pathophysiology
Background:
- Acute aortic rupture and dissection are uncommon but significant causes of sudden out-of-hospital death.
- Temporal patterns (circadian, seasonal, weekly) in the onset of aortic aneurysms are increasingly recognized, mirroring other acute cardiovascular events.
- These patterns suggest shared underlying mechanisms or disruptions in biological clock functions.
Purpose of the Study:
- To explore the potential temporal variations in the onset of aortic aneurysms.
- To investigate shared pathophysiological mechanisms contributing to cardiovascular events with temporal patterns.
- To hypothesize the role of biological clock dyssynchrony in cardiovascular disease and its rhythms.
Main Methods:
- Review of existing evidence on temporal patterns in cardiovascular events.
- Analysis of necropsy-confirmed causes of sudden death.
- Hypothetical exploration of molecular mechanisms and biological rhythms.
Main Results:
- Aortic aneurysms exhibit temporal onset variations, similar to myocardial infarction, stroke, and pulmonary embolism.
- Potential shared mechanisms include increased blood pressure, heart rate, sympathetic activity, and prothrombotic tendencies.
- Disruption of molecular mechanisms within the cardiomyocyte biological clock is a potential link.
Conclusions:
- Temporal variations in aortic aneurysm onset suggest common pathophysiological pathways with other cardiovascular diseases.
- Internal disruption of molecular mechanisms within the biological clock may contribute to cardiovascular disease.
- Further research is needed to elucidate the connection between biological rhythms and cardiovascular events.
Keywords:
Aortic aneurysmAortic aneurysm, abdominalAortic aneurysm, thoracicAortic ruptureBPBlood pressureChronobiologyCircadian rhythmIRADInternational Registry of Aortic DissectionMIMMPPMatrix metalloproteinaseMyocardial infarctionPEPulmonary embolismSCDSCNSeasonsSudden cardiac deathTIATIMPTissue inhibitors of matrix metalloproteinaseTransient ischemic attacksuprachiasmatic nucleus
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