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Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: May 8, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
06:55

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

Natural killer cell deficiency.

Jordan S Orange1

  • 1Immunology, Allergy, and Rheumatology, Baylor College of Medicine and the Texas Children's Hospital, Houston, Tex.

The Journal of Allergy and Clinical Immunology
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cell deficiency impacts innate immunity against viruses and cancer. Recent genetic discoveries clarify causes and pave the way for new NK cell therapies.

Keywords:
ADCCAntibody-dependent cell-mediated cytotoxicityCMVCNKDCTLClassical natural killer cell deficiencyCytomegalovirusCytotoxic T lymphocyteDOCK8Dedicator of cytokinesis 8FNKDFunctional natural killer cell deficiencyHPVHSVHerpes simplex virusHuman papillomavirusMCMMinichromosome maintenanceNKNKDNatural killerNatural killer cell deficiencyNatural killer cellsPIDPrimary immunodeficiencyVZVVaricella zoster viruscytotoxicityinnate immunitynatural killer cell deficiencyprimary immunodeficiency

More Related Videos

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Related Experiment Videos

Last Updated: May 8, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
06:55

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

Published on: February 22, 2020

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Area of Science:

  • Immunology
  • Genetics

Background:

  • Natural killer (NK) cells are crucial for innate immunity against viral infections and cancer.
  • Deficiencies in NK cell function significantly impair the immune system, often as part of congenital immunodeficiencies.
  • NK cell abnormalities can be the primary immunological defect in certain individuals.

Purpose of the Study:

  • To summarize current understanding of NK cell deficiency.
  • To highlight recent genetic discoveries in NK cell deficiency.
  • To discuss the implications for diagnosis and therapeutic strategies.

Main Methods:

  • Review of existing literature on NK cell deficiency.
  • Analysis of recent genetic studies identifying causative genes.
  • Discussion of clinical implications and potential treatments.

Main Results:

  • NK cell deficiency encompasses various genetic conditions affecting innate immunity.
  • Defects in at least 3 specific genes have been identified as causes of NK cell deficiency.
  • Understanding the genetic basis clarifies the underlying biology of these deficiencies.

Conclusions:

  • NK cell deficiency is a significant clinical issue with diverse genetic underpinnings.
  • Recent advances in genetic identification offer diagnostic clarity.
  • This knowledge facilitates the development of targeted therapeutic options for patients.