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Updated: May 8, 2026

A High-throughput, High-content, Liquid-based C. elegans Pathosystem
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Published on: July 1, 2018

C. elegans for anti-infective discovery.

Marios Arvanitis1, Justin Glavis-Bloom, Eleftherios Mylonakis

  • 1Division of Infectious Diseases, Warren Alpert Medical School of Brown University, United States.

Current Opinion in Pharmacology
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

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The soil nematode Caenorhabditis elegans is a powerful model for discovering new antimicrobial compounds. Its use in high-throughput screening accelerates the identification of novel anti-infective agents to combat drug-resistant pathogens.

Area of Science:

  • Microbiology
  • Parasitology
  • Drug Discovery

Background:

  • Antimicrobial resistance (AMR) is a growing global health threat, necessitating novel anti-infective strategies.
  • Traditional antimicrobial agents are facing challenges due to widespread resistance.
  • There is an urgent need for innovative compounds to combat multidrug-resistant pathogens.

Purpose of the Study:

  • To highlight the utility of Caenorhabditis elegans as a model organism for identifying novel anti-infective compounds.
  • To showcase the potential of C. elegans in discovering agents that target microbial virulence and enhance host immunity.
  • To emphasize the role of high-throughput screening in accelerating anti-infective drug discovery.

Main Methods:

  • Utilizing Caenorhabditis elegans as a model host for screening potential anti-infective agents.

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Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans
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Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans

Published on: February 27, 2012

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
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The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Related Experiment Videos

Last Updated: May 8, 2026

A High-throughput, High-content, Liquid-based C. elegans Pathosystem
09:44

A High-throughput, High-content, Liquid-based C. elegans Pathosystem

Published on: July 1, 2018

Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans
10:58

Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans

Published on: February 27, 2012

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
11:58

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

  • Employing high-throughput automated screening assays to test large numbers of substances.
  • Identifying compounds with microbicidal activity, virulence attenuation, or host immune-enhancement properties.

    • Main Results:

    • Caenorhabditis elegans has proven effective in identifying both traditional and novel anti-infective compounds.
    • The model system successfully detects agents that reduce microbial virulence.
    • It also identifies compounds that bolster the host's immune defenses against pathogens.

    Conclusions:

    • The C. elegans model offers a robust platform for the discovery of novel anti-infective drugs.
    • Its amenability to high-throughput screening makes it a valuable tool in the fight against antimicrobial resistance.
    • Scientific attention is increasingly focused on C. elegans for its potential in developing next-generation anti-infectives.