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Updated: May 8, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Sleep disturbances and reduced work functioning in depressive or anxiety disorders
Josine G van Mill1, Nicole Vogelzangs, Witte J G Hoogendijk
1Department of Psychiatry and the EMGO Institute for Health and Care Research, The Netherlands; NeuroCampus Amsterdam, VU University Medical Center Amsterdam, The Netherlands.
Sleep disturbances like insomnia and short sleep duration significantly impair work performance and increase absenteeism in individuals with psychopathology. These associations persist regardless of disorder severity or medication.
Area of Science:
- Epidemiology
- Sleep Medicine
- Occupational Health
Background:
- Sleep disturbances are common in individuals with depressive or anxiety disorders.
- The impact of these disturbances on work functioning is not fully understood.
- Understanding this relationship is crucial for comprehensive patient care and workplace productivity.
Purpose of the Study:
- To investigate the association between sleep disturbances and work functioning.
- To analyze these associations in individuals with and without psychopathology.
- To determine if these associations are independent of clinical factors.
Main Methods:
- Epidemiologic cohort study including 707 subjects with psychopathology and 728 without.
- Insomnia assessed using the Insomnia Rating Scale (score ≥9).
- Sleep duration categorized (short, normal, long). Work functioning assessed via absenteeism and performance.
- Logistic regression analyses were employed to examine associations.
Main Results:
- In subjects with psychopathology, insomnia and short sleep duration were linked to impaired work performance (ORs 2.20 and 2.54, respectively).
- Insomnia and short sleep duration were also associated with long-term absenteeism (ORs 2.48 and 1.85, respectively).
- These associations remained significant after controlling for clinical characteristics.
- No significant associations were found in subjects without psychopathology.
Conclusions:
- Sleep disturbances negatively impact work functioning in individuals with psychopathology.
- This impact is independent of disorder severity and psychotropic medication use.
- Further research is warranted to explore if treating sleep disturbances improves work functioning.
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