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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genetic Material01:20

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
Genetic Lingo01:11

Genetic Lingo

Overview
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

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Related Experiment Video

Updated: May 8, 2026

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

Gene-centric content management system.

Ekaterina V Poverennaya1, Nadezhda A Bogolubova, Nikolay N Bylko

  • 1Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences (RAMS), Russia.

Biochimica Et Biophysica Acta
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

The Human Proteome Project (HPP) developed a Gene-centric Content Management System (GenoCMS) to compare public and proprietary proteomic data. This tool aids in assessing HPP

Keywords:
Heat-mapHuman Proteome ProjectIntegrative bioinformaticsKnowledge baseTrack viewTraffic light

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Pattern-based Search of Epigenomic Data Using GeNemo
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Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Area of Science:

  • Proteomics
  • Bioinformatics
  • Computational Biology

Background:

  • The Human Proteome Project (HPP) aims to advance proteomic knowledge.
  • Existing data resources require integration and comparison with experimental findings.
  • Baseline metrics are needed to evaluate HPP's contribution.

Purpose of the Study:

  • To develop a web-based tool for comparing public and proprietary proteomic data.
  • To create a collaborative knowledge base for gene set annotation.
  • To visualize proteomic experiment results using a color-coded system.

Main Methods:

  • Development of a Gene-centric Content Management System (GenoCMS).
  • Integration of public data from NeXtProt, MS/MS repositories, Human Protein Atlas, and RNAseqAtlas.
  • Representation of proteomic data using heat-map/traffic light visualization.

Main Results:

  • GenoCMS enables comparison of public resources with proprietary experimental results.
  • A collaborative knowledge base for gene set annotation and web dissemination was established.
  • Proteomic data is presented as a color-coded catalog for enhanced understanding.

Conclusions:

  • GenoCMS provides a valuable platform for managing and comparing proteomic data.
  • The system facilitates collaborative annotation and knowledge sharing within the HPP.
  • Visual representation aids in interpreting complex proteomic experimental data.