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Updated: Apr 28, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Towards Metabolomics-Guided Healthy and Anti-Aging Nutrition.

Petr G Lokhov¹, Elena E Balashova¹, Dmitry L Maslov¹

¹Institute of Biomedical Chemistry, Pogodinskaya St. 10, Moscow 119121, Russia.

|April 27, 2026

Summary

Researchers developed a precision nutrition strategy using metabolomics to guide dietary changes for health. This approach can accurately track biological age, paving the way for personalized nutrition interventions.

Keywords:

aging diet diseases healthspan metabolomic fingerprinting precision nutrition

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Published on: April 22, 2022

Area of Science:

Metabolomics
Nutritional Science
Biogerontology

Background:

Metabolomic studies reveal metabolic shifts in aging and disease.
Translating complex metabolomic data into practical nutrition is challenging.
The metapathway, a network of key metabolites, offers a simplified approach.

Purpose of the Study:

To develop a precision nutrition framework using metabolomics.
To identify key metabolites for monitoring metabolic health.
To translate metabolomic insights into actionable dietary guidelines.

Main Methods:

Conceptualized a precision nutrition framework.
Selected a baseline diet and identified food/supplements for modification.
Employed mass spectrometry-based metabolome fingerprinting for response assessment.
Validated using blood plasma and dried blood spot samples.

Main Results:

Developed a metabolomics-guided precision nutrition strategy.
Demonstrated the ability to assess diet outcomes via metabolic fingerprinting.
Accurately determined biological age changes (within 1 month).

Conclusions:

A comprehensive metabolomics-guided nutrition strategy has been established.
The strategy is ready for human trials to confirm its health benefits.
This approach holds translational potential for personalized health interventions.