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The tableting properties of melibiose monohydrate
Satu Lakio1, Janne Sainio, Petteri Heljo
1Division of Pharmaceutical Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5E) 00014, Finland.
Melibiose, a sugar similar to lactose, shows potential as a tableting excipient. Its deformation behavior and compactibility were studied, revealing fragmenting properties comparable to lactose monohydrate.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Melibiose is a disaccharide structurally similar to lactose, composed of galactose and glucose.
- Understanding melibiose's tableting properties is crucial for its potential pharmaceutical applications.
Purpose of the Study:
- To investigate the tableting properties of alpha-melibiose monohydrate.
- To compare melibiose's compactibility and deformation behavior with alpha-lactose monohydrate and other excipients.
- To assess the impact of moisture on melibiose tabletability.
Main Methods:
- Comparative analysis of compactibility and deformation behavior using Heckel plots.
- Determination of yield pressure values and strain rate sensitivity (SRS) indexes.
- Evaluation of moisture effects on tablet tensile strength and compactibility.
Main Results:
- Melibiose exhibits fragmenting behavior, indicated by yield pressures and SRS indexes, similar to or greater than lactose monohydrate.
- Overall deformation behavior of melibiose closely resembles that of lactose monohydrate.
- Increased moisture content enhanced tablet tensile strength for both melibiose batches, with varying effects on compactibility.
Conclusions:
- Melibiose demonstrates potential as a tableting excipient due to its comparable deformation behavior to lactose monohydrate.
- Its fragmenting characteristics are well-defined and comparable to established excipients.
- Moisture content significantly influences the tabletability of melibiose, offering formulation flexibility.
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