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Related Experiment Video

Updated: May 8, 2026

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

Pump controlled retrograde trial off from VA-ECMO.

Claire Westrope1, Christopher Harvey, Simon Robinson

  • 1Heartlink ECMO Centre, Glenfield Hospital, Leicester, United Kingdom. Claire.westrope@uhl-tr.nhs.uk

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 3, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a new Pump Controlled Retrograde Trial Off method for venoarterial extracorporeal membrane oxygenation. It safely reduces support duration without circuit issues or hemodynamic compromise in neonates.

Related Experiment Videos

Last Updated: May 8, 2026

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

Area of Science:

  • Cardiovascular Medicine
  • Neonatal Intensive Care
  • Medical Devices

Background:

  • Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a life-support measure for neonates with severe cardiac or respiratory failure.
  • Traditional methods for weaning patients off VA-ECMO can be limited by circuit complications and hemodynamic instability.
  • Prolonged VA-ECMO support increases the risk of complications, necessitating safe and effective trial-off strategies.

Purpose of the Study:

  • To describe a novel Pump Controlled Retrograde Trial Off technique for VA-ECMO.
  • To evaluate the safety and efficacy of this technique in facilitating longer trial-off periods.
  • To assess the impact on circuit integrity and patient hemodynamics.

Main Methods:

  • The Pump Controlled Retrograde Trial Off technique utilizes retrograde flow to maintain circuit integrity during VA-ECMO weaning.
  • This method avoids the need for an arteriovenous bridge or circuit clamping.
  • The technique was applied to five neonatal patients requiring VA-ECMO support.

Main Results:

  • The novel technique allowed for extended trial-off periods from VA-ECMO support.
  • No instances of circuit clot formation were observed during the trial-off periods.
  • Patients experienced no significant hemodynamic compromise during the weaning process.
  • The method proved feasible and safe in the studied neonatal cohort.

Conclusions:

  • Pump Controlled Retrograde Trial Off is a safe and effective strategy for weaning neonatal patients from VA-ECMO.
  • This technique enhances circuit stability and patient hemodynamics during support reduction.
  • It offers a promising alternative to traditional trial-off methods, potentially reducing complications associated with prolonged VA-ECMO.