Related Experiment Video
Updated: Jul 1, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Nitric oxide in Extracorporeal Membrane Oxygenation Sweep Gas Promotes Oxygenator Longevity: A Technical Case Report
Yuriy Stukov1, Tavenner Dibert1, Zasha Vázquez-Colón1
1From the Congenital Heart Center, Departments of Surgery and Pediatrics, University of Florida.
None:
In the accompanying article in this issue, we reported the survival of a 4 month old infant with severe necrotizing pneumonia due to respiratory syncytial virus (RSV) and methicillin-resistant Staphylococcus aureus (MRSA), resulting in cardiogenic shock and respiratory failure, who required a total of 233 days of extracorporeal membrane oxygenator (ECMO) support. In this article, we report the function of the ECMO membrane (oxygenator). To preserve oxygenator function, nitric oxide was added to the ECMO sweep gas (sNO). Despite prolonged ECMO support, a single membrane lung functioned effectively for 5 months. Structural analysis of the polymethylpentene (PMP) oxygenator postdecannulation revealed no thrombus or fibrin deposition. This is the first known structural evaluation of a PMP oxygenator after prolonged clinical use with sNO, suggesting that sNO may prolong oxygenator longevity and maintain functional performance.
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