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Updated: May 8, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Structure-function relationships of factor Xa inhibitors: implications for the practicing clinician
Benjamin A Steinberg1, Richard C Becker
1Duke University Medical Center, PO Box 17969, Durham, NC, 27715, USA, benjamin.steinberg@duke.edu.
Journal of Thrombosis and Thrombolysis
|September 3, 2013
Summary
Novel oral anticoagulants offer improved efficacy but pose new clinical management challenges due to their specific binding, drug interactions, and renal clearance. This review details their development, pharmacokinetics, utility, and pitfalls.
Area of Science:
- Pharmacology
- Drug Development
- Internal Medicine
Background:
- Novel oral anticoagulants (NOACs) have been developed as targeted therapeutics.
- These agents offer advantages over warfarin but introduce new clinical management complexities.
- Their high bioavailability and target affinity result in potent anticoagulant effects.
Purpose of the Study:
- To review the development and pharmacokinetic properties of NOACs.
- To discuss the clinical utility and challenges associated with NOACs.
- To provide insights into the pharmacologic management of these novel agents.
Main Methods:
- Literature review of NOAC development.
- Analysis of pharmacokinetic data for NOACs.
- Evaluation of clinical studies on NOACs' efficacy and safety.
Main Results:
- NOACs exhibit high oral bioavailability and specific target binding.
- Renal clearance and drug interactions present unique management considerations.
- Understanding these properties is crucial for effective clinical application.
Conclusions:
- NOACs represent a significant advancement in anticoagulant therapy.
- Careful consideration of pharmacokinetics and potential interactions is essential for safe and effective use.
- Further research and clinical experience will refine NOAC management strategies.
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