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Updated: May 8, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Immunosuppression for interstitial lung disease in systemic sclerosis.
Susanna Cappelli1, Serena Guiducci, Silvia Bellando Randone
1Dept of Biomedicine, University of Florence, Florence, Italy.
Summary
Immunosuppressors may slow systemic sclerosis-interstitial lung disease progression, though they cannot reverse fibrosis. Early cyclophosphamide induction is recommended, with mycophenolate mofetil or rituximab as alternatives, followed by maintenance therapy.
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Systemic sclerosis-interstitial lung disease (SSc-ILD) treatment efficacy remains debated.
- Fibrotic lung changes in SSc-ILD are often irreversible.
Purpose of the Study:
- To review evidence on immunosuppressors for SSc-ILD.
- To evaluate the role of immunosuppressors in slowing disease progression.
Main Methods:
- Literature review analyzing existing studies on immunosuppressive therapies for SSc-ILD.
- Focus on evidence regarding disease progression and fibrotic changes.
Main Results:
- Immunosuppressors may not reverse fibrosis but can potentially slow SSc-ILD progression.
- Early cyclophosphamide induction is advised for at-risk patients.
- Mycophenolate mofetil and rituximab are alternatives for cyclophosphamide-intolerant patients.
- Maintenance therapy with mycophenolate mofetil or azathioprine is recommended post-remission.
Conclusions:
- Immunosuppressive therapy is a valuable strategy for managing SSc-ILD progression.
- Treatment should be individualized based on patient tolerance and disease status.
- Long-term maintenance therapy is crucial for sustained benefits.
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