Related Experiment Video

Updated: May 8, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuin 3: A major control point for obesity-related metabolic diseases?

Sean A Newsom1, Kristen E Boyle, Jacob E Friedman

  • 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO USA.

Drug Discovery Today. Disease Mechanisms
|September 3, 2013
PubMed

Insights

Mitochondrial sirtuin 3 may be a potential therapeutic target for treating obesity and related metabolic diseases, addressing a growing global health concern. Further research is needed to explore this promising avenue for intervention.

Area of Science:

  • Biochemistry
  • Metabolic Diseases
  • Mitochondrial Biology

Background:

  • Obesity and its complications represent a significant global health burden.
  • Increasing morbidity, mortality, and economic costs are associated with obesity-related conditions.

Purpose of the Study:

  • To review emerging evidence on mitochondrial sirtuin 3 (SIRT3).
  • To discuss the potential of SIRT3 as a therapeutic target for obesity-related metabolic diseases.
  • To identify remaining questions in the field.

Main Methods:

  • Literature review of current research on mitochondrial sirtuin 3.
  • Analysis of evidence linking SIRT3 to metabolic regulation.
  • Discussion of potential therapeutic strategies targeting SIRT3.

Main Results:

  • Emerging evidence suggests a role for mitochondrial sirtuin 3 in metabolic regulation.
  • SIRT3 activity may influence pathways relevant to obesity and related complications.
  • The precise mechanisms and therapeutic efficacy require further investigation.

Conclusions:

  • Mitochondrial sirtuin 3 presents a potential therapeutic target for obesity-related metabolic diseases.
  • Further research is warranted to elucidate SIRT3's role and develop targeted interventions.
  • Addressing obesity through novel targets like SIRT3 is crucial for public health.

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...