Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 8, 2026

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

Growth factor-mediated vertical mandibular ridge augmentation: a case report.

Kevin A Guze1, Emilio Arguello, David Kim

  • 1Department of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. kevin_guze@hsdm.harvard.edu

The International Journal of Periodontics & Restorative Dentistry
|September 3, 2013
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender Authorship in Gastroenterology and Hepatology: Trends and Persistent Seniority Gaps.

Journal of gastroenterology and hepatology·2026
Same author

AI counseling agent for motivational interviewing: Conversational processes associated with change talk in emergency department patients.

Journal of substance use and addiction treatment·2026
Same author

TFG-Containing Fusions in Melanocytic Tumors: From Polymorphic Read-Through Transcripts to Oncogenic Kinase Fusions.

Journal of cutaneous pathology·2026
Same author

Immunometabolic remodeling of perivascular adipose tissue in murine lupus: implications for lupus vasculopathy.

bioRxiv : the preprint server for biology·2026
Same author

Developing a Clinically Practical Biomaterial Platform for Endogenous Liver Regeneration.

Gels (Basel, Switzerland)·2026
Same author

Legionella Pneumonia Associated With Rhabdomyolysis and Acute Renal Failure: A Case Report.

Cureus·2026

Recombinant human platelet-derived growth factor BB combined with freeze-dried bone allograft shows promise for regenerating vertical alveolar ridge height. This approach may offer a viable alternative to traditional bone grafting for dental implant preparation.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Posterior vertical alveolar ridge deficiencies pose significant challenges for predictable treatment.
  • Conventional methods like guided bone regeneration, distraction osteogenesis, and autogenous grafts have limitations and potential complications.
  • Advances in recombinant growth factor technology offer potential alternative therapies for alveolar ridge defects.

Observation:

  • This case report investigates a composite graft of freeze-dried bone allograft and recombinant human platelet-derived growth factor BB (rhPDGF-BB).
  • The graft was used with a titanium mesh to regenerate bone in a posterior mandibular ridge defect.
  • The study highlights the role of the periosteum as a potential source of osteogenic cells.

Findings:

More Related Videos

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Related Experiment Videos

Last Updated: May 8, 2026

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

  • The composite graft successfully regenerated well-vascularized bone in a significant posterior mandibular ridge defect.
  • This technique demonstrated effectiveness in preparing the site for dental implant placement.
  • The combination of rhPDGF-BB and allograft shows potential for vertical bone regeneration.

Implications:

  • This regenerative approach may offer a less invasive alternative to autogenous bone harvesting.
  • The findings suggest a promising role for rhPDGF-BB in bone regeneration for dental applications.
  • Further research is warranted to validate these findings in larger clinical studies.