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Update on the challenging role of biofilms in peritoneal dialysis

Margarida Martins1, Anabela Rodrigues, Jorge M Pedrosa

  • 1IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Braga, Portugal.

Biofouling
|September 4, 2013
PubMed

Insights

Biofilms on peritoneal dialysis (PD) catheters and surrounding tissues contribute to persistent infections. Understanding these microbial communities is crucial for improving patient outcomes in PD-related peritonitis.

Area of Science:

  • Microbiology
  • Nephrology
  • Infectious Diseases

Background:

  • Biofilms significantly increase the risk of patient infections, particularly in peritoneal dialysis (PD).
  • Catheter-associated infections, especially peritonitis, are a persistent clinical challenge in PD patients.
  • The role of biofilms in recurrent and catheter-related peritonitis is recognized but not fully understood.

Purpose of the Study:

  • To provide an updated review on the role of biofilms in PD infections.
  • To discuss the contribution of host-associated biofilms to infection recalcitrance.
  • To examine evidence of biofilms on PD catheters, their development, and the influence of the PD environment.

Main Methods:

  • Review of ex vivo and in vitro studies.
  • Analysis of the interplay between host, microbial, and dialysis factors.
  • Synthesis of current knowledge on biofilm formation in PD.

Main Results:

  • Biofilms are present on PD catheters and contribute to treatment resistance.
  • Host cells and tissues can harbor biofilms, exacerbating infections.
  • The PD environment may influence biofilm development and persistence.

Conclusions:

  • Biofilms, including those on host tissues, are critical factors in the recalcitrance of PD infections.
  • Further research is needed to elucidate the complex interactions involved.
  • Addressing biofilm challenges is essential for improving clinical practice in PD.

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