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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
What is the Immune System?01:38

What is the Immune System?

Overview
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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Related Experiment Video

Updated: May 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferon-γ and systemic autoimmunity.

Kenneth M Pollard1, David M Cauvi, Christopher B Toomey

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. mpollard@scripps.edu

Discovery Medicine
|September 4, 2013
PubMed
Summary
This summary is machine-generated.

Interferon-gamma (IFN-γ) is crucial in systemic autoimmunity, particularly lupus. Targeting IFN-γ in adaptive immunity offers potential therapeutic benefits for autoimmune diseases.

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

  • Immunology
  • Autoimmunity
  • Molecular Biology

Background:

  • Interferons (IFNs) are protein families (Types I, II, III) regulating immune responses.
  • IFNs are key effectors in autoimmunity pathogenesis, especially systemic forms.
  • Type I IFNs are early responders, while Type II IFN (IFN-γ) is vital for systemic autoimmunity development and severity.

Purpose of the Study:

  • To explore the role of Type II Interferon (IFN-γ) in systemic autoimmunity.
  • To investigate the complex mechanisms of IFN-γ expression in adaptive immunity.
  • To identify potential therapeutic targets within IFN-γ's role in autoimmune diseases.

Main Methods:

  • Review of existing studies on interferon function in immunity and autoimmunity.
  • Analysis of animal models (spontaneous and induced) of lupus erythematosus.
  • Examination of IFN-γ's expression pathways in innate and adaptive immune cells.

Main Results:

  • IFN-γ is essential for the development and severity of systemic autoimmunity, including lupus.
  • Animal studies consistently show IFN-γ is required in lupus models.
  • IFN-γ expression in adaptive immunity involves intricate cellular and signaling pathways.

Conclusions:

  • IFN-γ plays a critical role in systemic autoimmune diseases like lupus.
  • The complex regulation of IFN-γ in adaptive immunity presents multiple therapeutic targets.
  • Targeting IFN-γ pathways holds promise for treating systemic autoimmunity.