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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

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LongevityMap: a database of human genetic variants associated with longevity.

Arie Budovsky¹, Thomas Craig, Jingwei Wang

¹The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; Judea Regional Research and Development Center, Carmel 90404, Israel.

Trends in Genetics : TIG

|September 4, 2013

Summary

Scientists created LongevityMap, a unique database detailing genes, loci, and variants linked to human longevity and healthy aging. This resource aids in understanding the genetic factors influencing a long and healthy life.

Keywords:

GWAS ageing genetics humans lifespan polymorphisms

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Area of Science:

Genetics
Gerontology
Bioinformatics

Background:

Understanding the genetic underpinnings of human longevity is crucial for developing interventions against age-related diseases.
Research into longevity genetics is complex, requiring comprehensive data integration.

Purpose of the Study:

To introduce LongevityMap, the first comprehensive database for genes, loci, and variants associated with human longevity and healthy aging.
To provide a centralized resource for researchers investigating the genetic basis of a long lifespan.

Main Methods:

Development of a specialized database, LongevityMap.
Curating and integrating genetic data related to human longevity and aging from various studies.

Main Results:

The LongevityMap database is now available, offering a unique collection of genetic information.
The database includes genes, loci, and variants studied in the context of human longevity and healthy aging.

Conclusions:

LongevityMap serves as a valuable tool for advancing the study of human longevity genetics.
The database facilitates research into life-extending interventions and treatments for age-related conditions.