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Updated: Dec 30, 2025
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates
Zhengwang Chen1, Dongnai Ye, Guohai Xu
1School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China. chenzwang@126.com lxliu@mail.xmu.edu.cn.
Abstract:
A highly efficient synthesis of a wide range of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in moderate to excellent yields with a broad substrate scope, including a variety of aromatic and aliphatic haloenol acetates.
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