Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diaphragmatic relaxation masquerading as COPD].

Khirurgiia·2025
Same author

[Treatment of postoperative complications in cardiothoracic surgery: single-center 10-year experience].

Khirurgiia·2024
Same author

[Features of course of pain syndrome in patients with schwannomatosis].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2024
Same author

[ICG angiography in prevention of colorectal anastomotic leakage].

Khirurgiia·2023
Same author

[Enhanced recovery program in thoracoabdominal surgery].

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury·2021
Same author

[Impact of comorbid chronic heart failure with preserved left ventricular ejection fraction on the management of elderly cancer patients before and after total resections].

Khirurgiia·2021

Related Experiment Video

Updated: May 8, 2026

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

[Coxibs for postoperative analgesia].

A G Voloshin, V V Nikoda

    Anesteziologiia I Reanimatologiia
    |September 5, 2013
    PubMed
    Summary

    Selective COX-2 inhibitors offer effective postoperative pain relief with analgesic and opioid-sparing benefits. They are a safe alternative to NSAIDs for specific patient groups and show potential in cancer treatment.

    Area of Science:

    • Pharmacology
    • Oncology
    • Pain Management

    Context:

    • Postoperative pain management is crucial for patient recovery.
    • Traditional NSAIDs and opioids have limitations in efficacy and safety.
    • The role of selective COX-2 inhibitors in multimodal analgesia requires further elucidation.

    Purpose:

    • To evaluate the efficacy and safety of coxibs in postoperative pain management.
    • To compare coxibs with other analgesics like NSAIDs, paracetamol, and opioids.
    • To explore the potential of coxibs in preventing adhesions and inhibiting tumor angiogenesis.

    Summary:

    • Coxibs demonstrate significant analgesic and opioid-sparing effects, comparable or superior to NSAIDs and paracetamol in specific postoperative settings.
    • They offer a safer profile than NSAID/PPI combinations for patients at risk of gastrointestinal complications and are suitable for those with aspirin-exacerbated respiratory disease.

    Related Experiment Videos

    Last Updated: May 8, 2026

    Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
    05:39

    Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

    Published on: June 23, 2023

  • Potential applications include inhibiting adhesion formation post-laparotomy and suppressing tumor angiogenesis by targeting vascular endothelial growth factor.

    • Impact:

    • Coxibs represent a valuable class of non-opioid analgesics for postoperative pain.
    • Their unique safety profile expands treatment options for specific patient populations.
    • Emerging evidence suggests novel therapeutic roles beyond pain management, particularly in oncology.