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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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In Ovo Intravascular Injection in Chicken Embryos
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Published on: June 3, 2022

Dynamic behaviour of selected PET tracers in embryonated chicken eggs.

P Gebhardt1, L Würbach, A Heidrich

  • 1Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, Germany.

Revista Espanola De Medicina Nuclear E Imagen Molecular
|September 5, 2013
PubMed
Summary

Positron emission tomography/computer tomography (PET/CT) imaging in chicken embryos shows potential for new tracers. Researchers evaluated several radiolabeled compounds for in vivo studies, finding specific uptake patterns useful for monitoring biological processes.

Keywords:
(18)F(64)Cu evaluación trazador(64)Cu tracer evaluation(68)GaAlternative modelChick embryoEmbrión de polloIn ovoIn vivoMicroPET/CTMicroPET/TCModelo alternativo

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Area of Science:

  • Nuclear medicine
  • Preclinical research
  • In vivo imaging

Background:

  • Positron emission tomography/computer tomography (PET/CT) is vital for preclinical research and clinical cancer diagnosis.
  • It integrates functional biomarker data with anatomical CT imaging for 4D in vivo biological process investigation.
  • Chicken embryos are emerging as a valuable in vivo model system for biological studies.

Purpose of the Study:

  • To investigate the suitability of additional PET/CT tracers in chicken embryos.
  • To evaluate various positron-emitting compounds for in vivo applications in this model.
  • To assess the properties of novel tracers in catheterized chicken eggs.

Main Methods:

  • Evaluation of (18)F-, (68)Ga-labelled tracers, and (64)Cu-chloride in chicken embryos using small animal microPET/CT.
  • Synthesis of tracers not commercially available.
  • Monitoring tracer uptake and distribution in catheterized eggs.

Main Results:

  • 2-Deoxy-2-[(18)F]fluoroglucose ([(18)F]FDG) showed primary absorption at bone growth sites.
  • (64)Cu chloride and a (68)Ga-labelled amyloid-fibril-binding antibody accumulated in the liver.
  • A (68)Ga-albumin desferrioxamine conjugate signal decreased in the liver over time.

Conclusions:

  • The evaluated biomarkers demonstrate potential for monitoring biological processes in chicken embryos.
  • Chicken embryos serve as a viable in vivo model for PET/CT tracer development and evaluation.
  • Further research can leverage these tracers for advanced in vivo studies in avian models.