Related Experiment Video
Updated: May 8, 2026

A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses
Published on: November 4, 2025
[The prevalence of yaws among the Aka in the Congo]
M Coldiron1, D Obvala, I Mouniaman-Nara
1mcoldiron@epicentre.msf.org
Insights
A 2012 study in Congo screened 6215 children for yaws (endemic treponemiasis), finding 7.8% with lesions. The Morges strategy used rapid diagnostic tests to identify cases for azithromycin treatment, aiding eradication efforts.
Area of Science:
- Tropical medicine
- Public health
- Infectious disease epidemiology
Context:
- Yaws (endemic treponemiasis) is a neglected tropical disease prevalent in endemic areas.
- The Congo, specifically the Bétou and Enyellé districts, faces a significant burden of yaws.
- Effective screening and treatment strategies are crucial for controlling and eradicating yaws.
Purpose:
- To screen children for yaws in two districts of the Congo.
- To evaluate the effectiveness of a rapid diagnostic test for treponema in identifying yaws cases.
- To assess the prevalence of yaws among children with dermatological problems.
Summary:
- A 2012 study screened 6215 children in Congo for yaws.
- Clinical history and examination identified 485 children with suspicious dermatological lesions.
- A rapid diagnostic test for treponema was positive in 183 (38.1%) of 480 tested children.
Impact:
- The study identified a 7.8% prevalence of yaws lesions among screened children.
- The findings support the Morges strategy for yaws eradication through early detection and single-dose azithromycin treatment.
- This approach can significantly contribute to reducing the burden of yaws in endemic regions.
Abstract:
This study, conducted in 2012 in two districts of the Congo (Bétou and Enyellé), screened for yaws (endemic treponemiasis) that could be treated by a single dose of azithromycin. The screening involved a clinical history, followed by a clinical examination of the children reporting dermatological problems. A rapid diagnostic test for treponema was performed on the children with suspicious lesions. Of 6215 children screened, 485 (7.8%) had such lesions; 480 (99.0%) of them had a rapid diagnostic test, and it was positive for 183 (38.1%). This so-called Morges strategy is aimed at eradicating yaws in endemic areas.
Related Concept Videos
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Infectious Diseases and Their Occurrence
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...

