Related Experiment Video
Updated: May 8, 2026
09:56
A Rat Model of Tibial Cortex Transverse Transport for the Treatment of Lower Limb Ischemia
Published on: March 6, 2026
Ischemic Charcot foot: different disease with different treatment?
L M Palena1, E Brocco, S Ninkovic
1Interventional Radiology Unit, Policlinico Abano Terme Abano Terme, Padua, Italy. marianopalena@hotmail.com
The Journal of Cardiovascular Surgery
|September 5, 2013
Summary
Peripheral arterial disease and Charcot neuroarthropathy in diabetic patients can lead to critical limb ischemia. Revascularization, combined with surgical and orthopedic care, significantly improves limb salvage rates, aiding in foot healing.
Area of Science:
- Vascular Surgery
- Diabetology
- Orthopedics
Background:
- Diabetic patients with Charcot neuroarthropathy often present with peripheral arterial disease and critical limb ischemia.
- Foot lesions in these patients require comprehensive management strategies.
Purpose of the Study:
- To describe the occurrence of peripheral arterial disease in diabetic patients with Charcot neuroarthropathy.
- To evaluate the effectiveness of revascularization in supporting surgical and orthopedic treatments for limb and foot salvage.
Main Methods:
- Retrospective analysis of diabetic patients with Charcot neuroarthropathy and critical limb ischemia treated between January 2010 and January 2012.
- Patients underwent endovascular revascularization followed by surgical debridement and orthopedic correction.
- Primary endpoint: limb salvage rate; Secondary endpoint: lesion healing time.
Main Results:
- Ten patients (10 men, mean age 69.1 years) with ischemic Charcot neuroarthropathy were treated.
- A limb salvage rate of 90% was achieved, avoiding major amputation in 9 patients.
- Mean healing time for lesions was 197.4 days post-treatment.
Conclusions:
- Charcot foot deformity can coexist with critical limb ischemia in diabetic patients.
- Revascularization is crucial for supporting surgical and orthopedic treatments.
- This combined approach effectively avoids amputation and promotes limb and foot salvage.
Related Concept Videos
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
01:26Peripheral Artery Disease IV: Nursing Management
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
01:29Cardiomyopathy V: Interprofessional Care
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...