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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Subventricular zone cytoarchitecture changes in autism.

Prasanti Kotagiri1, Steven A Chance, Francis G Szele

  • 1Department of Neuropathology (Nuffield Department of Clinical Neuroscience), Oxford University Hospitals, University of Oxford, United Kingdom; Department of Medicine (Neuroscience), Monash University, Australia; Royal Melbourne Hospital, Australia.

Developmental Neurobiology
|September 5, 2013
PubMed
Summary
This summary is machine-generated.

Autism impacts the brain's subventricular zone (SVZ), affecting cell density and proliferation differently in septal versus striatal regions, especially with epilepsy. These findings suggest unique neurodevelopmental trajectories in autism.

Keywords:
adult neurogenesisautismrostral migratory streamseptumsubventricular zone

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The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
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Published on: May 6, 2010

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Autism Spectrum Disorder Research

Background:

  • Autism is a neurodevelopmental disorder linked to neonatal neurogenesis in the subventricular zone (SVZ).
  • Autism-associated genes affect SVZ proliferation and structure, but human SVZ responses in autism remain unclear.
  • Epilepsy influences neurogenesis in rodents, yet its interaction with autism in SVZ responses is unknown.

Purpose of the Study:

  • To investigate the human subventricular zone (SVZ) in individuals with autism compared to controls.
  • To determine if autism differentially affects the striatal and septal SVZ, considering epilepsy co-morbidity.
  • To examine age-related changes and cell proliferation markers within the SVZ in autism.

Main Methods:

  • Post-mortem immunohistochemical examination of the human SVZ from individuals with autism (n=11) and controls (n=11).
  • Analysis of cell density, proliferation markers (PCNA, Ki67), and glial markers (GFAP) in septal and striatal SVZ regions.
  • Assessment of cell types including ependymal, astrocyte ribbon, and RMS cells for specific protein expression.

Main Results:

  • Autism showed reduced septal SVZ hypocellular gap cell density, but only in the absence of epilepsy.
  • Septal hypocellular gap cells declined with age in autism, unlike in controls.
  • Increased PCNA+ cells were observed in the septal SVZ (hypocellular gap and ependymal layer) in autism with epilepsy.
  • Ependymal cells became GFAP immunoreactive in autism (striatal side only), irrespective of epilepsy.
  • A subset of SVZ, ependymal, astrocyte ribbon, and RMS cells expressed proliferation and neuronal markers.

Conclusions:

  • This study provides the first evidence of differential effects of a neuropsychiatric disease on the septal and striatal SVZ.
  • Altered cell density and proliferation in the SVZ suggest distinct neurodevelopmental trajectories in individuals with autism.
  • The findings highlight the complex interplay between autism, epilepsy, and SVZ neurogenesis.