Related Experiment Video
Updated: May 8, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
Published on: July 29, 2022
Cohen's d needs to be readily interpretable: comment on Shieh (2013)
1Statistical Cognition Laboratory, School of Psychological Science, La Trobe University, Melbourne, Victoria, 3086, Australia, g.cumming@latrobe.edu.au.
This study critiques Shieh's delta-star (δ*) effect size measure for heteroscedasticity, finding it inconsistent with Cohen's d and lacking generalizability for meta-analysis. It recommends using population standard deviation estimates for Cohen's d instead.
Area of Science:
- Statistics
- Psychometrics
- Quantitative Psychology
Background:
- Standardized effect sizes are crucial for interpreting research findings.
- Shieh (2013) proposed delta-star (δ*) as a standardized effect size for two-independent-groups designs with heteroscedasticity.
- Shieh's work focused on the inferential challenges, particularly confidence interval calculation for δ*.
Purpose of the Study:
- To evaluate the appropriateness of the standardizer used for δ*.
- To assess the consistency of δ* with conventional Cohen's d.
- To examine the generalizability and meta-analytic utility of δ*.
Main Methods:
- Conceptual analysis of effect size measures.
- Comparison of δ* with Cohen's d under heteroscedasticity.
- Evaluation of standardizer choice and its impact on interpretation and meta-analysis.
Main Results:
- The standardizer for δ* is suitable for inference but creates inconsistency with Cohen's d.
- δ* is dependent on relative sample sizes, limiting its generality.
- The proposed δ* measure is less interpretable and less suitable for meta-analysis compared to alternatives.
Conclusions:
- Researchers should prefer Cohen's d standardized by the best estimate of the population standard deviation (e.g., control population SD) over δ* when dealing with heteroscedasticity.
- The choice of standardizer significantly impacts the interpretability and meta-analytic application of effect size measures.
- Alternative standardization strategies for Cohen's d are recommended for heteroscedastic conditions.
Related Concept Videos
Bioequivalence Data: Statistical Interpretation
Chi-square Analysis
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Cochran's Q Test
Interpretation of Confidence Intervals
Confidence intervals have confidence coefficients that are crucial for their interpretation. The most common confidence coefficients are 0.90, 0.95, and 0.99, which can be written as percentages–90%, 95%, and 99%, respectively.
Suppose a person calculates a confidence interval with a confidence coefficient of 0.95. In that case, they can...
Kohlraush’s Law and its Applications
Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
