Related Experiment Video
Updated: May 8, 2026
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Obesity and metabolic inflammation.
1Hallett Center for Diabetes and Endocrinology, Division of Endocrinology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903.
Drug Discovery Today. Disease Mechanisms
|September 5, 2013
Summary
Obesity and its associated metabolic disorders are linked to chronic inflammation. This review explores anti-inflammation strategies as potential treatments for obesity-related conditions.
Area of Science:
- Metabolic disorders and inflammation research.
Background:
- Obesity affects over a third of US adults and 17% of children, leading to serious health issues like type 2 diabetes and cardiovascular disease.
- Obesity-related health problems incurred an estimated $147 billion in medical costs in 2008.
- Chronic inflammation, especially in adipose tissue, is a key factor in developing obesity-related metabolic syndrome.
Purpose of the Study:
- To review recent advancements in understanding metabolic inflammation.
- To discuss the potential of anti-inflammation therapies for treating obesity-related metabolic disorders.
Main Methods:
- This is a review article, synthesizing current research on metabolic inflammation and anti-inflammation therapies.
- Literature search and analysis of recent scientific publications in the field of metabolic inflammation and obesity.
Main Results:
- Adipose tissue inflammation is a critical mechanism in obesity-related metabolic dysfunction.
- Emerging research highlights the role of inflammation in various obesity-associated comorbidities.
- Anti-inflammation approaches show promise as therapeutic interventions.
Conclusions:
- Targeting metabolic inflammation offers a potential therapeutic avenue for managing obesity and its associated health complications.
- Further research into anti-inflammation strategies could lead to novel treatments for metabolic syndrome.
- Understanding the link between obesity, inflammation, and metabolic disorders is crucial for public health.
Related Concept Videos
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
01:24Overview of Lipid Metabolism
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...