Related Experiment Video
Updated: May 8, 2026
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
The immune cells in adipose tissue.
1Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA. awf7@columbia.edu
Diabetes, Obesity & Metabolism
|September 6, 2013
Summary
The immune system actively monitors and responds to metabolic signals, a field known as immunometabolism. This interaction is crucial in metabolic disorders like obesity, influencing immune cell function in key tissues such as adipose tissue.
Area of Science:
- Immunometabolism research bridges immunology and metabolic disease.
- Focuses on the immune system's role in local and systemic metabolism.
Background:
- The immune system's role in metabolic disorders is increasingly recognized.
- Immunometabolism describes immune responses to metabolic cues.
Purpose of the Study:
- To review immune cell modulation in adipose tissue.
- To discuss regulatory processes at the metabolism-immunology interface.
Main Methods:
- Literature review of immunometabolism research.
- Analysis of immune cell recruitment and activation in metabolic tissues.
Main Results:
- Metabolic processes, particularly obesity, activate innate and adaptive immunity.
- Immune surveillance and metabolic modulation occur in liver, muscle, hypothalamus, and pancreas.
- Adipose tissue is a key site for studying immune-metabolic interactions.
Conclusions:
- The immune system plays a significant role in metabolic health and disease.
- Understanding immunometabolism offers insights into metabolic complications.
- Adipose tissue immune cell function is critical for metabolic regulation.
Related Concept Videos
01:28Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
01:26Loose Connective Tissue
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...