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Updated: May 8, 2026
Generation of Transgenic Rats using a Lentiviral Vector Approach
Published on: May 17, 2020
Low titer lentiviral transgenesis in rodents with simian immundeficiency virus vector
Balázs Bender1, Orsolya Ivett Hoffmann, Didier Negre
1Institute of Animal Biotechnology, Agricultural Biotechnology Center, Gödöllő, Hungary.
Abstract:
Efficient production of transgenic animals using low-titer lentiviral constructs remains challenging. Here we demonstrate that microinjection of simian immundeficiency virus-derived lentiviral constructs can produce transgenic mice and rats with high efficiency even when using low-titer virus preparations.
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