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Related Experiment Video

Updated: May 8, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Nodal marginal zone lymphoma.

Maria K Angelopoulou¹, Christina Kalpadakis, Gerassimos A Pangalis

¹Department of Hematology and Bone Marrow Transplantation.

Leukemia & Lymphoma

|September 6, 2013

Summary

Nodal marginal zone lymphoma (NMZL) is an indolent B-cell cancer. While radiotherapy is used for localized NMZL, advanced stages benefit from rituximab, though more research is needed.

Keywords:

NMZL lymphoma marginal zone

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Area of Science:

Hematology
Oncology
Immunology

Background:

Nodal marginal zone lymphoma (NMZL) is a subtype of marginal zone lymphoma, accounting for about 10% of cases.
NMZL often presents as advanced nodal disease and shares characteristics with splenic marginal zone lymphoma (SMZL) and mucosa-associated lymphoid tissue (MALT) lymphoma.
Despite an indolent course, NMZL has a less favorable prognosis than SMZL and MALT lymphoma.

Purpose of the Study:

To review the characteristics, prognosis, and treatment of Nodal Marginal Zone Lymphoma.
To highlight the challenges in managing NMZL due to its rarity and the need for collaborative research.

Main Methods:

Review of existing literature on Nodal Marginal Zone Lymphoma.
Analysis of treatment outcomes from retrospective series and larger indolent lymphoma cohorts.

Main Results:

Radiotherapy is the preferred treatment for localized NMZL.
Rituximab-based therapies are recommended for advanced-stage NMZL.
Reported 5-year overall survival rates for NMZL range from 55% to 89%.

Conclusions:

NMZL requires thorough staging to rule out extranodal involvement.
Evidence-based treatment recommendations are limited by the rarity of NMZL, necessitating international collaboration.
Further research is crucial to understand NMZL biology and optimize treatment strategies.