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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Updated: May 8, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
10:35

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Published on: December 26, 2017

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells.

Marcia A Chan1, Nicole M Gigliotti, Abby L Dotson

  • 1Department of Pediatrics, Division of Immunology Research, Children's Mercy Hospitals & Clinics, Kansas City, MO 64108, USA. machan@cmh.edu.

Clinical and Translational Allergy
|September 6, 2013
PubMed
Summary
This summary is machine-generated.

Omalizumab, an anti-IgE antibody, reduces viable B cells in humans, not by apoptosis, but by decreasing IgE synthesis. This suggests a new mechanism for treating allergic asthma.

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Area of Science:

  • Immunology
  • Allergology
  • Cell Biology

Background:

  • Omalizumab is a humanized anti-IgE monoclonal antibody used for allergic asthma.
  • Treatment with omalizumab leads to decreased serum IgE, eosinophils, and B cells.
  • In vitro and animal studies suggest omalizumab inhibits IgE synthesis and eliminates IgE-expressing cells.

Purpose of the Study:

  • To investigate the effect of omalizumab on human B cell survival and IgE synthesis genes.
  • To determine the mechanism by which omalizumab affects B cells.

Main Methods:

  • Human tonsillar B cells were stimulated to produce IgE using IL-4 and anti-CD40 antibody.
  • Omalizumab was added in the presence or absence of these stimuli.
  • Cell viability and gene expression related to IgE synthesis were analyzed.

Main Results:

  • Omalizumab reduced the number of viable B cells, but not through apoptosis.
  • Levels of IL-4R and germline Cϵ mRNA were decreased.
  • The number of membrane IgE+ B cells was reduced.

Conclusions:

  • Omalizumab may decrease IgE synthesis in human B cells.
  • The mechanism involves targeting membrane IgE-bearing B cells.
  • Omalizumab may induce anergy or tolerance in these cells.