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Related Experiment Video

Updated: May 8, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

An anatomical substrate for integration among functional networks in human cortex.

Martijn P van den Heuvel¹, Olaf Sporns

¹Department of Psychiatry, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. M.P.vandenheuvel@umcutrecht.nl

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|September 6, 2013

Summary

The human brain

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Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

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Area of Science:

Neuroscience
Network Science
Brain Imaging

Background:

The human brain exhibits efficient network properties, with specialized functional communities (resting-state networks or RSNs).
The structural organization of these RSNs and their interconnections remain poorly understood.
The 'rich club' is a network of highly interconnected hub regions in the brain's structural network.

Purpose of the Study:

To investigate the role of the brain's rich club in linking functional resting-state networks (RSNs).
To understand how structural connectivity supports functional integration between RSNs.

Main Methods:

Combined high-resolution diffusion-weighted imaging (DWI) with resting-state functional magnetic resonance imaging (fMRI).
Analyzed structural connectivity patterns and their relationship with functional network organization.

Main Results:

Rich club hubs are present in all functional networks and overlap in regions where multiple networks converge.
A significant portion of connections between RSNs involve rich club nodes.
Rich club connections are crucial for communication pathways linking different RSNs.

Conclusions:

The brain's rich club acts as a key anatomical structure for cross-linking macroscopic functional networks.
This rich club organization is vital for integrating information across segregated functional domains in the human cortex.