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Resolution of a left ventricular thrombus by the thrombolytic action of dabigatran

Yasutsugu Nagamoto1, Tetsuya Shiomi, Taku Matsuura

  • 1Division of Cardiology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga city, 840-8571, Japan, sqopacificsouthern1978@yahoo.co.jp.

Heart and Vessels
|September 6, 2013
PubMed

Insights

This study shows dabigatran effectively dissolved a pre-existing left ventricular thrombus in a patient with previous myocardial infarction. The treatment demonstrated a thrombolytic effect, resolving the intracardiac thrombus without causing thromboembolism.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • A 77-year-old male presented with abnormal electrocardiography findings.
  • Preoperative evaluation revealed a left ventricular (LV) thrombus (14 x 12 mm) secondary to previous myocardial infarction with anteroseptal akinesis.

Observation:

  • The patient was treated with dabigatran (220 mg/day) as an outpatient.
  • Serial ultrasound echocardiography (UCG) and computed tomography (CT) were used for monitoring.

Findings:

  • Complete resolution of the LV thrombus was confirmed by UCG and CT 27 days after initiating dabigatran.
  • No thromboembolic events occurred during the treatment period.

Implications:

  • Dabigatran exhibits a thrombolytic effect on acute, pre-existing intracardiac thrombi.
  • This finding suggests a potential therapeutic role for dabigatran in managing LV thrombi.

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