[The study of procognitive effect of the potential antipsychotic, Dilept and its main metabolite, GZR-125 at the...

The effect of dipeptidal neurotensine mimetic, N-caproyl-L-prolyl-L-tyrosine methyl ester (GZR-123, Dilept) and its main metabolite N-caproyl-L-prolyl-L-tyrosine (GZR-125) was evaluated at novel objects recognition test (NOR) in the male outbred rats. NOR was chosen from many cognitive test as those involving the selective action on the attention and episodic memory and considering as translational model for the study of cognition deficiency in schizophrenics. M-cholinoblocking agent scopolamine (0.2 mg/kg s.c.) was used as agent disturbing the performance of the test. Dilept (2 mg/kp i.p.) was shown to restore the NOR performance, disturbed by scopolamine. The same was true for GZR-125 (2 mg/kp i.p.), whose cholinopositive effect could contribute to the procognitive effect of the parent molecule.