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Updated: May 8, 2026

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
Published on: May 27, 2021
Thermal fluctuations in shape, thickness, and molecular orientation in lipid bilayers. II. Finite surface tensions
Max C Watson1, Alex Morriss-Andrews, Paul M Welch
1NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
Abstract:
We investigate the role of lipid chemical potential on the shape, thickness, and molecular orientation (lipid tilting relative to the monolayer surface normal) of lipid bilayers via a continuum-level model. We predict that decreasing the chemical potential at constant temperature, which is associated with an increase in surface tension via the Gibbs-Duhem relation, leads both to the well known reduction in thermal membrane undulations and also to increasing fluctuation amplitudes for bilayer thickness and molecular orientation. These trends are shown to be in good agreement with molecular simulations, however it is impossible to achieve full quantitative agreement between theory and simulation within the confines of the present model. We suggest that the assumption of lipid volume incompressibility, common to our theoretical treatment and other continuum models in the literature, may be partially responsible for the quantitative discrepancies between theory and simulation.
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