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Related Experiment Video

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Spatially resolved assessment of hepatic function using 99mTc-IDA SPECT.

Hesheng Wang1, Yue Cao

  • 1Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA. hesheng@umich.edu

Medical Physics
|September 7, 2013
PubMed
Summary

This study introduces a novel voxel-by-voxel method to assess liver function using 99mTc-iminodiacetic acid (IDA) SPECT/CT. This technique, utilizing vascular input function, significantly improves the accuracy of hepatic extraction fraction (HEF) measurements compared to traditional methods.

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Hepatology

Background:

  • Quantifying liver function typically involves analyzing the entire liver or specific regions of interest (ROIs).
  • Accurate, spatially resolved assessment of hepatic function is crucial for evaluating liver disease and treatment response.

Purpose of the Study:

  • To develop and validate a voxel-by-voxel method for estimating hepatic extraction fraction (HEF) using 99mTc-iminodiacetic acid (IDA) SPECT/CT.
  • To evaluate the accuracy of this spatially resolved HEF measurement against an independent physiological assessment.

Main Methods:

  • Fourteen patients with intrahepatic cancers underwent 99mTc-mebrofenin SPECT/CT before and after radiation therapy.
  • Voxelwise HEF was calculated using deconvolution analysis, comparing arterial input function (AIF) and vascular input function (VIF) from the spleen.
  • Correlation with Indocyanine green clearance half-time (T1/2) and ROI-based variation were assessed.

Main Results:

  • Voxelwise HEF estimation using VIF showed a strong correlation with T1/2 (r = 0.79, p < 0.0001), significantly outperforming AIF (r = 0.52, p = 0.0004).
  • The time range parameter for retention phase did not significantly impact HEF means in ROIs.
  • Relative variation of voxelwise HEF in ROIs was 10% ± 6% using VIF and a 7-30 min retention phase.

Conclusions:

  • Voxelwise HEF derived from 99mTc-IDA SPECT/CT via deconvolution analysis is a feasible method.
  • This approach enables accurate assessment of the spatial distribution of hepatic function within the liver.